STAT signaling in inflammation

STAT signaling in inflammation

Since their discovery, STAT proteins have been intimately tied to controlling the development of hematopoietic cells that regulate inflammation, and mediating the responses of target cells to inflammatory cytokines. Although our understanding of STAT protein-dependent gene expression during inflammation has grown considerably over the past 15 years, the identification of new cell types that req...

The Jak-Stat Signaling Pathway of Interferons System: Snapshots

Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...

SnapShot: JAK-STAT Signaling

the jak-stat signaling pathway of interferons system: snapshots

interferons (ifns) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. although ifns have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. ifns exert their pleiotropic effects through their multisubunit cell surface recept...

Involvement of JAK-STAT signaling/function after cyclophosphamide-induced bladder inflammation in female rats.

Cytokines are upregulated in a variety of inflammatory conditions and cytokine/receptor interactions can activate JAK-STAT signaling. Previous studies demonstrated upregulation of numerous cytokines in the urinary bladder following cyclophosphamide (CYP)-induced cystitis. The role of JAK-STAT signaling in urinary bladder inflammation and referred somatic sensitivity has not been addressed. The ...